The relation of liver kynureninase to tryptophan metabolism in pyridoxine deficiency.
نویسنده
چکیده
Birch, A. J. (1950). Rep. Progr. Chem. 47, 177. Crombie, L. & Harper, S. H. (1950). J. chem. Soc. p. 2685. Fredga, A. (1941). Ark. Kemi Min. Geol. 14B, no. 27. Fredga, A. (1942). Ark. Kemi Mmn. Geol. 15B, no. 23. Fredga, A. (1944). The Svedberg 1884.1944,p. 261. Uppsala: Almqvist and Wicksells. Hansen, R. P., Shorland, F. B. & Cooke, N. J. (1952). Biochem. J. 52, 203. Hansen, R. P., Shorland, F. B. & Cooke, N. J. (1953). * Biochem. J. 53, 374. Klyne, W. (1951). Chem. & Ind. p. 1022. Marckwald, W. (1899). Ber. dtsch. chem. Gee. 82, 1089. Marckwald, W. & Nolda, E. (1909). Ber. dtech. chem. Gem. 42, 1583. Stillberg-Stenhagen, S. (1949). Ark. Kemi, 1, 187. StOlberg-Stenhagen, S. (1950). Ark. Kemi, 2, 95. Tschugaeff, L. (1898). Ber. dt8ch. chem. Ge8. 81, 360. Velick, S. F. & English, J., jun. (1945). J. biol. Chem. 160, 473. Weitkamp, A. W. (1945). J. Amer. chem. Soc. 67,447. Welt, I. (1894). C.R. Acad. Sci., Pari, 119, 855.
منابع مشابه
The intermediary metabolism of tryptophan by cat and rat tissue preparations.
Reports from several laboratories have shown that cats display a peculiar tryptophan metabolism as compared with other mammals. In 1941, Kotake and Nakayama (1) reported that L-kynurenine could be quantitatively converted to anthranilic acid when incubated with cat liver preparations. Gordon, Kaufman, and Jackson (a), on the other hand, found no kynurenic acid in urine of cats even when tryptop...
متن کاملThe influence of vitamin B6 on the formation of liver pyridine nucleotides.
It has been shown that, when tryptophan is administered to rats, an increased excretion of niacin and some of its derivatives occurs (l-4). Isotope studies by Heidelberger et al. (5, 6) have given further evidence that niacin can be derived from tryptophan in the animal body. Vitamin Bs has been implicated in this transformation, since in a pyridoxine deficiency the excretion of an abnormal met...
متن کاملEffect of pyridoxine on tryptophan metabolism in rheumatoid arthritis.
In a previous paper (Bett, 1962), it was reported that a majority of patients with rheumatoid arthritis excreted abnormal amounts of the tryptophan metabolites, 3-hydroxyanthranilic acid and kynurenine. In these experiments the most striking difference between control subjects and patients with rheumatoid arthritis was in the urinary kynurenine output after a loading dose of L-tryptophan. This ...
متن کاملEffects of oestradiol and vitamin B6 on tryptophan metabolism in the rat: implications for the interpretation of the tryptophan load test for vitamin B6 nutritional status.
1. The effects of the administration of oestradiol and vitamin B, on tryptophan metabolism in the rat have been assessed by measurement of the release of 14C0, from [14C]tryptophan, in vivo, in order to determine whether, and to what extent, the abnormalities of tryptophan metabolism that are associated with oestrogen administration can be attributed to drug-induced vitamin B, deficiency or dep...
متن کاملTryptophan Metabolism in Rat Liver After Administration of Tryptophan, Kynurenine Metabolites, and Kynureninase Inhibitors
Rat liver tryptophan (Trp), kynurenine pathway metabolites, and enzymes deduced from product/substrate ratios were assessed following acute and/or chronic administration of kynurenic acid (KA), 3-hydroxykynurenine (3-HK), 3-hydroxyanthranilic acid (3-HAA), Trp, and the kynureni-nase inhibitors benserazide (BSZ) and carbidopa (CBD). KA activated Trp 2,3-dioxygenase (TDO), possibly by increasing ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Biochemical journal
دوره 53 3 شماره
صفحات -
تاریخ انتشار 1953